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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
33.33
Human Site:
T564
Identified Species:
52.38
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
T564
L
K
L
H
Y
N
V
T
T
T
R
L
V
N
P
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
T564
L
K
L
H
Y
N
V
T
T
T
R
L
V
N
P
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
V564
L
K
F
I
I
N
I
V
L
T
E
P
V
N
P
Dog
Lupus familis
XP_538730
651
74149
T564
L
K
L
H
Y
N
V
T
T
T
R
L
V
N
P
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
T556
R
K
L
H
Y
N
V
T
T
T
R
L
V
N
P
Rat
Rattus norvegicus
P54645
559
63955
T488
I
T
E
A
K
S
G
T
A
T
P
Q
R
S
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
T568
L
R
A
H
Y
N
V
T
T
T
K
L
V
N
P
Chicken
Gallus gallus
NP_001026680
657
74208
T570
L
K
A
H
Y
N
V
T
M
T
Q
L
L
N
P
Frog
Xenopus laevis
NP_001081569
651
74289
T564
L
R
A
H
Y
N
V
T
T
T
N
I
V
N
P
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
S821
R
V
L
G
K
Q
L
S
A
D
N
A
E
T
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
A535
C
T
E
D
D
K
D
A
M
R
P
F
S
S
R
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
S617
V
K
N
M
V
N
V
S
M
T
A
S
Q
D
P
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
T884
K
A
L
Y
N
V
S
T
T
S
T
L
P
A
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
K369
L
G
F
D
V
Q
K
K
N
Y
K
M
R
L
E
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
T556
K
Y
D
I
G
N
K
T
N
T
N
E
K
I
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
46.6
100
N.A.
93.3
13.3
N.A.
80
73.3
73.3
6.6
N.A.
N.A.
0
33.3
26.6
P-Site Similarity:
100
100
53.3
100
N.A.
93.3
33.3
N.A.
93.3
86.6
86.6
20
N.A.
N.A.
6.6
53.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
20
7
0
0
0
7
14
0
7
7
0
7
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
14
7
0
7
0
0
7
0
0
0
7
7
% D
% Glu:
0
0
14
0
0
0
0
0
0
0
7
7
7
0
7
% E
% Phe:
0
0
14
0
0
0
0
0
0
0
0
7
0
0
0
% F
% Gly:
0
7
0
7
7
0
7
0
0
0
0
0
0
0
7
% G
% His:
0
0
0
47
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
7
0
0
14
7
0
7
0
0
0
0
7
0
7
0
% I
% Lys:
14
47
0
0
14
7
14
7
0
0
14
0
7
0
0
% K
% Leu:
54
0
40
0
0
0
7
0
7
0
0
47
7
7
0
% L
% Met:
0
0
0
7
0
0
0
0
20
0
0
7
0
0
0
% M
% Asn:
0
0
7
0
7
67
0
0
14
0
20
0
0
54
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
14
7
7
0
67
% P
% Gln:
0
0
0
0
0
14
0
0
0
0
7
7
7
0
0
% Q
% Arg:
14
14
0
0
0
0
0
0
0
7
27
0
14
0
7
% R
% Ser:
0
0
0
0
0
7
7
14
0
7
0
7
7
14
0
% S
% Thr:
0
14
0
0
0
0
0
67
47
74
7
0
0
7
0
% T
% Val:
7
7
0
0
14
7
54
7
0
0
0
0
47
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
7
47
0
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _